personal photo of Christian Meyer

Christian Meyer

Tagline:Postdoctoral Research Fellow at the University of Colorado Boulder. Recovering physicist working at the interface of systems biology and human health.

Boulder, CO, USA

About Me

Christian is the father of Elijah (7), Caleb (5), Micah (2), and the lucky husband of Elisabeth Meyer. Christian shares many personality traits with Owl from Winnie The Pooh including Owl's proclivity to use big words he can neither spell nor really define. Christian spends his days as a postdoctoral research fellow at the University of Colorado Boulder as a trained physicist working in a microbiology lab. His parents continue to wonder when he will get a real job.

Curriculum Vitae (CV)

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Research Interests

  • Discovery of synergistic drugs
  • Development of high throughput assays
  • Computation in natural systems

Education

  • Ph.D.

    from: 2014, until: 2020

    Field of study:Systems BiologySchool:Vanderbilt UniversityLocation:Nashville, TN

    Description

    During my thesis, I developed MuSyC, a mathematical model of drug synergy that integrates historically contradictory frameworks into a generalized consensus model. One critical advance of MuSyC is the separation between two types of synergistic interactions: synergistic efficacy and synergistic potency which enables the optimization of drug combinations along the clinical axes of interest: namely, increasing the therapeutic ceiling or
    ameliorating off-target toxicities. MuSyC has been applied in a myriad of diseases including non-small-cell lung cancer, melanoma, acute myeloid leukemia, glioblastoma, immunotherapy, and antimicrobial resistant bacteria.

  • B.S.

    from: 2010, until: 2014

    Field of study:Physics, Minor: MathematicsSchool:Colorado State UniversityLocation:Fort Collins, CO

Publications

  • Expanded profiling of WD repeat domain 5 inhibitors reveals actionable strategies for the treatment of hematologic malignancies

    Journal ArticlePublisher:Proceedings of the National Academy of SciencesDate:2024
    Authors:
    Christian T. MeyerBrianna N. SmithJing WangKevin B. TeuscherBrian C. GriebGregory C. HowardAlexander J. SilverShelly L. LoreyGordon M. StottWilliam J. MooreTaekyu LeeMichael R. SavonaApril M. WeissmillerQi LiuVito QuarantaStephen W. FesikWilliam P. Tansey
    DOI

  • Resistance to Spindle Inhibitors in Glioblastoma Depends on STAT3 and Therapy Induced Senescence

    DocumentPublisher:bioRxivDate:2024
    Authors:
    Natanael ZarcoAthanassios DovasVirginea de Araujo FariasNaveen KH NagaiahAshley HaddockPeter A. SimsDolores HambardzumyanChristian T. MeyerPeter CanollSteven S. RosenfeldRajappa S. Kenchappa
    DOI

  • MT-125 Inhibits Non-Muscle Myosin IIA and IIB, Synergizes with Oncogenic Kinase Inhibitors, and Prolongs Survival in Glioblastoma

    DocumentPublisher:bioRxivDate:2024
    Authors:
    Rajappa KenchappaLaszlo RadnaiErica J. YoungNatanael ZarcoLi LinAthanassios DovasChristian T. MeyerAshley HaddockAlice HallPeter CanollMichael D. CameronNaveen KH NagaiahGavin RumbaughPatrick R. GriffinTheodore M. KameneckaCourtney A. MillerSteven S. Rosenfeld
    DOI

  • Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host environment

    Journal ArticlePublisher:mBioDate:2023
    Authors:
    Samual C. AllgoodChih-Chia SuAmy L. CrooksChristian T. MeyerBojun ZhouMeredith D. BettertonMichael R. BarbachynEdward W. YuCorrella S. Detweiler
    DOI

  • Cell-autonomous diversification in bacteria arises from calcium dynamics self-organizing at a critical point

    Journal ArticlePublisher:Science AdvancesDate:2023
    Authors:
    Christian T. MeyerJoel M. Kralj
    DOI

  • A geometry-based approach to make viable-cell counting easy and cheap

    Journal ArticlePublisher:Nature MicrobiologyDate:2023
    Authors:
    DOI

  • A high-throughput and low-waste viability assay for microbes

    Journal ArticlePublisher:Nature MicrobiologyDate:2023
    Authors:
    Christian T. MeyerGrace K. LynchDana F. StamoEugene J. MillerAnushree ChatterjeeJoel M. Kralj
    DOI

  • A global sensitivity analysis of a mechanistic model of neoadjuvant chemotherapy for triple negative breast cancer constrained by in vitro and in vivo imaging data

    Journal ArticlePublisher:Engineering with ComputersDate:2023
    Authors:
    Guillermo LorenzoAngela M. JarrettChristian T. MeyerJulie C. DiCarloJohn VirostkoVito QuarantaDarren R. TysonThomas E. Yankeelov
    DOI

  • Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma

    Journal ArticlePublisher:Cell ReportsDate:2022
    Authors:
    Rajappa S. KenchappaAthanassios DovasMichael G. ArgenzianoChristian T. MeyerLauren E. StopferMatei A. BanuBrianna PereiraJessica GriffithAfroz MohammadSurabhi TaleleAshley HaddockNatanael ZarcoWilliam ElmquistForest WhiteVito QuarantaPeter SimsPeter CanollSteven S. Rosenfeld
    DOI

  • Translatome proteomics identifies autophagy as a resistance mechanism to on-target FLT3 inhibitors in acute myeloid leukemia

    Journal ArticlePublisher:LeukemiaDate:2022
    Authors:
    Sebastian E. KoschadeKevin KlannShabnam ShaidBinje VickJan A. StratmannMarlyn ThölkenLaura M. MeyerThe Duy NguyenJulia CampeLaura M. MoserSusanna HockFatima BakerChristian T. MeyerFrank WempeHubert ServeEvelyn UllrichIrmela JeremiasChristian MünchChristian H. Brandts
    DOI